Carbamate group as structural motif in drugs: a review of carbamate derivatives used as therapeutic agents
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چکیده
منابع مشابه
Urethan (ethyl carbamate) as a cosolvent of drugs commonly used parenterally in humans.
Urethan, a potent teratogenic and carcinogenic agent in experimental animals, has been used in Japan for the past 25 years as a cosolvent of water-insoluble analgesic and sedative drugs. Urethan is used also as a solubilizer and cosolvent for pesticides, fumigants, and cosmetics, because it is a good solvent for various organic materials (6). In the past, urethan was used clinically as an antin...
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Vinyl carbamate was much more active (10 to 50 times) than ethyl carbamate for the initiation of skin tumors and for the induction of lung adenomas in mice. Vinyl carbamate was also mutagenic to Salmonella typhimurium TA 1535 and TA 100 in the presence of reduced nicotinamide adenine dinucleotide phosphate-fortified rat or mouse liver mitochondrial supernatant fractions. This mutagenic activity...
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It has been commonly assumed that carbamate kinnse (EC 2.7.2.2, ATP : carbamate phospllotransferase) catalyzes the transfer of a phosphate group between 1TP and the carbamate ion. Evidence which has been put forward supporting this belief is the observation that freshly dissolved ammonium carbamate is a much better substrate for the enzyme than freshly dissolved ammonium carbonate at pH 9.4 (1)...
متن کاملThe electronic structure of carbamate derivatives as the inhibitors of cholinesterase.
伴 隆志 ・永田 親 義 The inhibition of cholinesterase by some of carbamates has attracted the attention of many researchers in relation to the clinical usefulness (1) and insecticidal activity (2, 3) of the compounds. In this paper the author's chief concern is mainly devoted to investigating the rela tionship between the electronic structure of several structurally related carbamate type cholinesteras...
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ژورنال
عنوان ژورنال: Archives of Industrial Hygiene and Toxicology
سال: 2020
ISSN: 0004-1254
DOI: 10.2478/aiht-2020-71-3466